Exosiris Technologies
Nanomedicine innovations
Revolutionizing therapeutic delivery for personalized medicine.
What are Exo-LNPs?
Extracellular vesicles and synthetic lipid nanoparticles are hybridized and functionalized to create a hybrid nanoparticle for specific and safe therapeutic in vivo delivery.
Exosomes are naturally occurring extracellular vesicles, that serve as biocompatible and cell-specific delivery vehicles, capable of carrying genetic material and proteins while evading immune detection.
Exosome–LNP hybrids enable in vivo delivery of active immunotherapies
A controlled loading methodology of fusion between EVs and mRNA-loaded liposomes enables a single-particle quality level.
Liponanopartcles (LNP) are widely used as drug delivery vesicles, but present several drawbacks like low biocompatibility and unfavorable immune response.
CAR-T engineering
What are CAR-T cells?
CAR-T cells are a type of immune cell that has been genetically engineered to recognize and kill cancer cells using a synthetic receptor called a chimeric antigen receptor (CAR).
CAR-T cells technology present major drawbacks
Although a major success in leukemia, current CAR-T therapy has shown frequent relapses and no second infusion is allowed. Besides, it presents a very high cost of manufacturing and efficacy in solid tumor has not been demonstrated.